TYMS

OMIMHGNC

Synonym(s): Tsase, TMS, HsT422, TS

Locus: 18p11.32

Tests

Test Type
Molecular (8)
Multi-Gene Panel (7)
Multi-Method Panel (2)
Test Method
Del/Dup (CNV) (1)
Mutation Scanning of Entire Coding Region (1)
Sequencing, Capillary (Sanger) (5)
Genotyping (Microarray, Beads, etc.) (2)
Sequencing, Next Gen (2)
Lab Location
Australia(1)
Spain(2)
Portugal(1)
USA(3)
Germany(1)
 
TheraGuide 5-FU
method(s): ◦ Mutation Scanning of Entire Coding Region 
Genetic Technologies Pty Ltd - Victoria, Australia
Susceptibility to Drugs (5-Fluoruracil), Sequencing DPYD Gene and Genotype (2R/2R,2R/3R,3R/3R) TYMS Gene
method(s): ◦ Genotyping (Microarray, Beads, etc.) ◦ Sequencing, Capillary (Sanger) 
Reference Laboratory Genetics - Hospitalet de Llobregat, Spain
5-fluorouracil toxicity (2 alleles on MTHFR, 1 allele on TYMS and 1 allele on DPYD genes)
method(s): ◦ Sequencing, Capillary (Sanger) 
CGC Genetics - Porto, Portugal
Toxicity to Fluoropyrimidines: DPYD gene and TYMS (2R / 2R, 2R / 3R o 3R / 3R) gene sequence analysis and genotype determination
method(s): ◦ Sequencing, Capillary (Sanger) 
GENETAQ, Molecular Genetics Centre - Malaga, Spain
TAT: 4-6 weeks
price: contact lab
Somatic Tumor Panel
method(s): ◦ Sequencing, Next Gen 
CeGaT GmbH - Tübingen, Germany
5-Fluorouracil (5-FU) Toxicity and Chemotherapeutic Response, 5 Mutations
method(s): ◦ Genotyping (Microarray, Beads, etc.) 
ARUP Laboratories, Molecular Genetics Laboratory - Salt Lake City, UT, USA
TAT: 4-5 Weeks
price: contact lab
TYMS
method(s): ◦ Sequencing, Next Gen ◦ Sequencing, Capillary (Sanger) ◦ Del/Dup (CNV) 
Fulgent Diagnostics - Temple City, CA, USA
TAT: 7-10 days
price: contact lab
Fluoropyrimidine Drug (5-FU) Sensitivity Genotyping, Blood
method(s): ◦ Sequencing, Capillary (Sanger) 
Mayo Clinic - Minnesota, Personalized Genomics Laboratory - Rochester, MN, USA