DSPP
Synonym(s): DMP3, DFNA39, DGI1
Locus: 4q22.1
Protein: Dentin sialophosphoprotein variant G
Disorders
- Dentin Dysplasia, Type II
- Dentinogenesis Imperfecta 1
- Dentinogenesis Imperfecta, Shields Type III
- Deafness, Autosomal Dominant 39 with Dentinogenesis
Tests
| Usher Syndrome method(s): ◦ Sequencing, Next Gen Asper Biotech Ltd., Asper Biotech - Tartu, Estonia |
| Hearing Loss: Sequencing Panel method(s): Emory University School of Medicine, Emory Molecular Genetics Laboratory - Atlanta, GA, USA |
| NGS of 4 genes: DSPP, MSX1, PTH1R, WNT10A. method(s): ◦ Mutation Scanning of Entire Coding Region ◦ Sequencing, Next Gen Sistemas Genomicos, Medical Genetics Unit - Paterna, Spain |
TAT: 12-16 weeks OtoSCOPEprice: $1,500.00 method(s): ◦ Sequencing, Next Gen University of Iowa Hospital and Clinics, Molecular Otolaryngology and Renal Research Laboratories - Iowa City, IA, USA |
| Dentinogenesis Imperfecta, Sequencing DSPP Gene method(s): ◦ Sequencing, Capillary (Sanger) Reference Laboratory Genetics - Hospitalet de Llobregat, Spain |
| Expanded Hearing Loss Panel, Sequencing (56 Genes) and Deletion/Duplication (53 Genes) method(s): ◦ Del/Dup (CNV) ◦ Sequencing, Next Gen ARUP Laboratories, Molecular Genetics Laboratory - Salt Lake City, UT, USA |
| Hearing Loss Panel method(s): ◦ Sequencing, Next Gen Genomic Laboratory of the DNA Research Center LTD (Centrum Badań DNA sp z o.o.) - Poznań, Poland |
| NewbornDx method(s): ◦ Sequencing, Next Gen Parabase Genomics - Boston, MA, USA |
| NewbornDx HL method(s): ◦ Sequencing, Next Gen Parabase Genomics - Boston, MA, USA |
| Non syndromic deafness AD, AR and XL (NGS panel of 79 genes) method(s): ◦ Sequencing, Next Gen CGC Genetics - Porto, Portugal |
| Syndromic and non syndromic deafness (NGS panel of 127 genes) method(s): ◦ Sequencing, Next Gen CGC Genetics - Porto, Portugal |
| Non syndromic deafness AD (NGS panel of 33 genes) method(s): ◦ Sequencing, Next Gen CGC Genetics - Porto, Portugal |
| Dentinogenesis Imperfecta, Panel Massive Sequencing (NGS) 4 Genes method(s): ◦ Sequencing, Next Gen Reference Laboratory Genetics - Hospitalet de Llobregat, Spain |
| Amelogenesis Imperfecta NGS Panel method(s): ◦ Sequencing, Next Gen ◦ Sequencing, Capillary (Sanger) ◦ Del/Dup (CNV) Fulgent Diagnostics - Temple City, CA, USA |
| DSPP method(s): ◦ Sequencing, Next Gen ◦ Sequencing, Capillary (Sanger) ◦ Del/Dup (CNV) Fulgent Diagnostics - Temple City, CA, USA |
| Hearing Loss NGS Panel method(s): ◦ Sequencing, Next Gen ◦ Sequencing, Capillary (Sanger) ◦ Del/Dup (CNV) Fulgent Diagnostics - Temple City, CA, USA |
TAT: 2-3 weeks Dentinogenesis Imperfecta (DGI) and Dentin Dysplasia (DD) via the DSPP Geneprice: $680.00 method(s): ◦ Sequencing, Capillary (Sanger) PreventionGenetics (Prevention Genetics), Clinical DNA Testing and DNA Banking - Marshfield, WI, USA |
TAT: 4 weeks Otogenetics Hearing Loss and Deafness Multi-Gene NGS Panelprice: $1,245.00 method(s): ◦ Sequencing, Next Gen Otogenetics Corporation - Atlanta, GA, USA |
| Deafness, autosomal dominant type 39, with dentinogenesis type 1 method(s): ◦ Sequencing, Capillary (Sanger) ◦ Del/Dup (CNV) Centogene AG, Rare Disease Company - Rostock, Germany |
| Dentinogenesis imperfecta, Shields type 3 method(s): ◦ Sequencing, Capillary (Sanger) ◦ Del/Dup (CNV) Centogene AG, Rare Disease Company - Rostock, Germany |
| Dentinogenesis imperfecta, Shields type 2 method(s): ◦ Sequencing, Capillary (Sanger) ◦ Del/Dup (CNV) Centogene AG, Rare Disease Company - Rostock, Germany |
| Dentin dysplasia, type 2 method(s): ◦ Sequencing, Capillary (Sanger) ◦ Del/Dup (CNV) Centogene AG, Rare Disease Company - Rostock, Germany |
TAT: 3-4 weeks Amelogenesis imperfecta and related disorders NGS panelprice: $1,570.00 method(s): ◦ Sequencing, Next Gen Connective Tissue Gene Tests - Allentown, PA, USA |
TAT: 2-3 weeks Amelogenesis imperfecta and related disorders NGS panelprice: $1,150.00 method(s): ◦ Del/Dup (CNV) Connective Tissue Gene Tests - Allentown, PA, USA |
TAT: 3-4 weeks Amelogenesis imperfecta and related disorders NGS panelprice: $2,570.00 method(s): ◦ Del/Dup (CNV) ◦ Sequencing, Next Gen Connective Tissue Gene Tests - Allentown, PA, USA |
| Comprehensive Hearing Loss and Deafness Panel method(s): ◦ Del/Dup (CNV) ◦ Sequencing, Next Gen Blueprint Genetics, Helsinki - Helsinki, Finland |
| Non-Syndromic Hearing Loss Panel method(s): ◦ Del/Dup (CNV) ◦ Sequencing, Next Gen Blueprint Genetics, Helsinki - Helsinki, Finland |
| Syndromic Hearing Loss Panel method(s): ◦ Del/Dup (CNV) ◦ Sequencing, Next Gen Blueprint Genetics, Helsinki - Helsinki, Finland |
| Comprehensive Hearing Loss and Deafness Panel method(s): ◦ Del/Dup (CNV) ◦ Sequencing, Next Gen Blueprint Genetics, San Francisco - San Francisco, CA, USA |
| Non-Syndromic Hearing Loss Panel method(s): ◦ Del/Dup (CNV) ◦ Sequencing, Next Gen Blueprint Genetics, San Francisco - San Francisco, CA, USA |
| Syndromic Hearing Loss Panel method(s): ◦ Del/Dup (CNV) ◦ Sequencing, Next Gen Blueprint Genetics, San Francisco - San Francisco, CA, USA |