CADASIL

Synonym(s): Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy

 

GeneReviewOMIM

GeneLocusProtein
NOTCH319p13.12Neurogenic locus notch homolog protein 3
Test Type
Molecular (55)
Multi-Gene Panel (9)
Multi-Method Panel (14)
Test Method
Del/Dup (CNV) (11)
Mutation Scanning of Select Exons (5)
Mutation Scanning of Entire Coding Region (1)
Sequencing, Capillary (Sanger) (39)
Repeat Expansion / Contraction (2)
Sequencing, Next Gen (14)
Prenatal/Carrier
Prenatal (6)
Carrier (8)
Lab Location
Canada(4)
Germany(15)
Slovakia(1)
Israel(1)
Spain(13)
United Kingdom(3)
Portugal(4)
USA(6)
Czech Republic(1)
Austria(1)
Korea, Republic of(2)
Turkey(3)
Bulgaria(1)


Test
CADASIL Test
method(s): ◦ Sequencing, Capillary (Sanger) 
Alberta Children's Hospital, Molecular Diagnostic Laboratory - Calgary, Canada
CADASIL Test
method(s): ◦ Sequencing, Capillary (Sanger) 
Diagenom GmbH, Medical Genetics Laboratory - Rostock, Germany
CADASIL Test
method(s): ◦ Sequencing, Capillary (Sanger) 
Medgene, MedGene - Bratislava, Slovakia
CADASIL Test
method(s): ◦ Sequencing, Capillary (Sanger) 
GGA - Galil Genetic Analysis - Kazerin, Israel
CADASIL Test
method(s): ◦ Sequencing, Capillary (Sanger) 
Instituto de Medicina Genómica, IMEGEN - Paterna (Valencia), Spain
CADASIL Test
method(s): ◦ Sequencing, Capillary (Sanger) 
Instituto de Medicina Genómica, IMEGEN - Paterna (Valencia), Spain
TAT: 4-8 weeks
price: contact lab
CADASIL Test
method(s): ◦ Sequencing, Capillary (Sanger) 
Exeter Molecular Genetics, Royal Devon & Exeter Hospital - Exeter, United Kingdom
CADASIL Test
method(s): ◦ Sequencing, Capillary (Sanger) 
CeGaT GmbH - Tübingen, Germany
TAT: 2-4 weeks
price: contact lab
CADASIL Test
method(s): ◦ Del/Dup (CNV) ◦ Sequencing, Capillary (Sanger) ◦ Sequencing, Next Gen 
Center for Human Genetics - University of Regensburg, Hehr Laboratory - Regensburg, Germany
CADASIL Test
method(s): ◦ Sequencing, Capillary (Sanger) 
Center for Human Genetics, Bioscientia GmbH - Ingelheim, Germany
CADASIL (sequence analysis of NOTCH3 gene)
method(s): ◦ Sequencing, Next Gen 
CGC Genetics - Porto, Portugal
CADASIL Test
method(s): ◦ Sequencing, Capillary (Sanger) 
Athena Diagnostics Inc - Marlborough, MA, USA
CADASIL Test
method(s): ◦ Sequencing, Capillary (Sanger) 
BC Children's and BC Women's Hospitals, Molecular Genetics Laboratory - Vancouver, Canada
CADASIL Test
method(s): ◦ Sequencing, Capillary (Sanger) 
bio.logis Center for Human Genetics - Frankfurt am Main, Germany
Cerebral Arteriopathy with Subcortical Infarcts and Leukoencephalopathy Test
method(s): ◦ Sequencing, Capillary (Sanger) 
General University Hospital in Prague, Institute of Inherited Metabolic Disorders - Praha, Czech Republic
CADASIL Test
method(s): ◦ Sequencing, Capillary (Sanger) 
GENETAQ, Molecular Genetics Centre - Malaga, Spain
CADASIL Test
method(s): ◦ Sequencing, Capillary (Sanger) 
GENETAQ, Molecular Genetics Centre - Malaga, Spain
CADASIL Test
method(s): ◦ Sequencing, Capillary (Sanger) 
Praxis fuer Humangenetik Wien - Vienna, Austria
TAT: 3-5 weeks
price: contact lab
CADASIL Test
method(s): ◦ Sequencing, Capillary (Sanger) 
London Health Sciences Centre, Molecular Diagnostic Laboratory - London, Ontario, Canada
CADASIL Test
method(s): ◦ Sequencing, Capillary (Sanger) 
Secugen S.L. - Madrid, Spain
CADASIL Test
method(s): ◦ Sequencing, Capillary (Sanger) 
Seoul National University Hospital, Molecular Diagnostics Laboratory - Seoul, Korea, Republic of
CADASIL Test
method(s): ◦ Sequencing, Capillary (Sanger) 
Sheffield Diagnostic Genetics Service - Sheffield, United Kingdom
CADASIL test
method(s): ◦ Mutation Scanning of Select Exons ◦ Sequencing, Capillary (Sanger) 
Medical Genetics Center, Asan Medical Center - Seoul, Korea, Republic of
TAT: 3-4 weeks
price: contact lab
Cadasil Disease (Exon 3, 4, 5, 6)
method(s): ◦ Sequencing, Capillary (Sanger) 
Biyolojik Bilimler Arastirma Gelistirme ve Uretim AS, Duzen Laboratuvarlar Grubu - Istanbul, Turkey
CADASIL
method(s): ◦ Sequencing, Capillary (Sanger) 
MVZ Dortmund Dr. Eberhard and Partner - Dortmund, Germany
TAT: 7-8 weeks
price: contact lab
Sanger sequencing of the NOTCH3 gene
method(s): ◦ Mutation Scanning of Entire Coding Region ◦ Sequencing, Capillary (Sanger) 
Sistemas Genomicos, Medical Genetics Unit - Paterna, Spain
TAT: 4-5 weeks
price: contact lab
Mutations in exons 2, 3 and 4 of the NOTCH3 gene
method(s): ◦ Sequencing, Capillary (Sanger) ◦ Mutation Scanning of Select Exons 
Sistemas Genomicos, Medical Genetics Unit - Paterna, Spain
TAT: 4-5 weeks
price: contact lab
Mutations in exons 5, 6 and 11 of the NOTCH3 gene
method(s): ◦ Sequencing, Capillary (Sanger) ◦ Mutation Scanning of Select Exons 
Sistemas Genomicos, Medical Genetics Unit - Paterna, Spain
CADASIL Syndrome, Sequencing Exons (3-4) NOTCH 3 Gene
method(s): ◦ Mutation Scanning of Select Exons 
Reference Laboratory Genetics - Hospitalet de Llobregat, Spain
CADASIL Syndrome, Sequencing Exons (2,5,6,11) NOTCH 3 Gene
method(s): ◦ Mutation Scanning of Select Exons 
Reference Laboratory Genetics - Hospitalet de Llobregat, Spain
CADASIL Syndrome, Sequencing NOTCH3 Gene
method(s): ◦ Sequencing, Capillary (Sanger) 
Reference Laboratory Genetics - Hospitalet de Llobregat, Spain
CADASIL (sequence analysis of exons 2 to 6 and 11 of NOTCH3 gene)
method(s): ◦ Sequencing, Capillary (Sanger) 
CGC Genetics - Porto, Portugal
CADASIL (sequence analysis of exons 1, 7-10, 12-33 of NOTCH3 gene)
method(s): ◦ Sequencing, Next Gen 
CGC Genetics - Porto, Portugal
CADASIL Test
method(s): ◦ Sequencing, Capillary (Sanger) 
Burc Molecular Genetics Laboratory - Istanbul, Turkey
CADASIL
method(s): ◦ Sequencing, Capillary (Sanger) 
L.E.S. Mikrogen Genetic Diagnosis Center - Ankara, Turkey
CADASIL [Cerebral Arteriopathy, Autosomal Dominant, with Subcortical Infarcts and Leukoencephalopathy
method(s): ◦ Sequencing, Capillary (Sanger) 
South West Thames Genetics Laboratory, St George's University of London - London, United Kingdom
TAT: 2-4 weeks
price: contact lab
Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy (CADASIL)
method(s): ◦ Sequencing, Next Gen 
Connective Tissue Gene Tests - Allentown, PA, USA
TAT: 3-5 weeks
price: contact lab
CADASIL syndrome (NOTCH3 sequencing)
method(s): ◦ Sequencing, Capillary (Sanger) 
Cidegen, SL - Salamanca, Spain
CADASIL Syndrome, Deletions-Duplications (MLPA) NOTCH3 Gene
method(s): ◦ Del/Dup (CNV) 
Reference Laboratory Genetics - Hospitalet de Llobregat, Spain
TAT: 3-5 weeks
price: contact lab
Teenager Stroke / Stroke-Like Episodes
method(s): ◦ Sequencing, Next Gen 
MGZ München, Medizinisch Genetisches Zentrum München - München, Germany
NOTCH3
method(s): ◦ Del/Dup (CNV) ◦ Sequencing, Capillary (Sanger) ◦ Sequencing, Next Gen 
MGZ München, Medizinisch Genetisches Zentrum München - München, Germany
TAT: 4-6 weeks
price: contact lab
Frontotemporal Dementia (FTD) Panel
method(s): ◦ Repeat Expansion / Contraction ◦ Sequencing, Next Gen 
CeGaT GmbH - Tübingen, Germany
TAT: 4-6 weeks
price: contact lab
Dementia all Panel
method(s): ◦ Del/Dup (CNV) ◦ Repeat Expansion / Contraction ◦ Sequencing, Next Gen 
CeGaT GmbH - Tübingen, Germany
TAT: 4-6 weeks
price: contact lab
Small Vessel Disease Panel
method(s): ◦ Sequencing, Next Gen 
CeGaT GmbH - Tübingen, Germany
TAT: 2-4 weeks
price: contact lab
Single gene testing NOTCH3
method(s): ◦ Del/Dup (CNV) ◦ Sequencing, Capillary (Sanger) 
CeGaT GmbH - Tübingen, Germany
TAT: 1-2 weeks
price: contact lab
Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy (CADASIL)
method(s): ◦ Del/Dup (CNV) ◦ Sequencing, Next Gen 
Connective Tissue Gene Tests - Allentown, PA, USA
TAT: 2-3 weeks
price: contact lab
Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy (CADASIL)
method(s): ◦ Del/Dup (CNV) 
Connective Tissue Gene Tests - Allentown, PA, USA
TAT: 8-10 weeks
price: contact lab
Comprehensive Neurogenetics Panel (290 genes)
method(s): ◦ Sequencing, Next Gen 
Sherbrooke Genomic Medicine - Sherbrooke, Canada
CADASIL Test
method(s): ◦ Del/Dup (CNV) 
bio.logis Center for Human Genetics - Frankfurt am Main, Germany
CADASIL Test
method(s): ◦ Del/Dup (CNV) ◦ Sequencing, Capillary (Sanger) 
GMDL Genica - Sofia, Bulgaria
TAT: 2-3 weeks
price: contact lab
NOTCH3
method(s): ◦ Del/Dup (CNV) ◦ Sequencing, Capillary (Sanger) ◦ Sequencing, Next Gen 
Fulgent Diagnostics - Temple City, CA, USA
TAT: 4 weeks
price: contact lab
CADASIL: NOTCH3 gene
method(s): ◦ Sequencing, Capillary (Sanger) 
GenoMed-Diagnosticos de Medicina Molecular, SA - Lisboa, Portugal
TAT: 3-5 weeks
price: $990.00
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) via the NOTCH3 Gene
method(s): ◦ Sequencing, Next Gen 
PreventionGenetics (Prevention Genetics), Clinical DNA Testing and DNA Banking - Marshfield, WI, USA
TAT: ~2 weeks
price: contact lab
CADASIL
method(s): ◦ Sequencing, Capillary (Sanger) 
Centogene AG, Rare Disease Company - Rostock, Germany
TAT: 4-5 weeks
price: contact lab
Leukodystrophy and peroxisome biogenesis disorders panel
method(s): ◦ Del/Dup (CNV) ◦ Sequencing, Next Gen 
Centogene AG, Rare Disease Company - Rostock, Germany