Disorders

Hereditary Sensory and Autonomic Neuropathy Type IV

Synonym(s): CIPA, Congenital Insensitivity to Pain with Anhidrosis, Hereditary Sensory and Autonomic Neuropathy Type IV, HSAN IV, HSAN Type IV, HSAN4

GeneReview OMIM

Gene	Locus	Protein
NTRK1	1q21-q22	High affinity nerve growth factor receptor

Laboratory	Test Method	Prenatal	Carrier *
Addenbrooke's Hospital, Molecular Genetics Laboratory - Cambridge, Great Britain
Athena Diagnostics Inc, Reference Lab - Worcester, MA, USA
bio.logis Center for Human Genetics - Frankfurt, Germany
Center for Human Genetics, Bioscientia GmbH - Ingelheim, Germany
Centogene AG, Rare Disease Company - Rostock, Germany
Diagenom GmbH, Medical Genetics Laboratory - Rostock, Germany
diagenos - Osnabrueck, Germany
GeneDx - Gaithersburg, MD, USA
GENETAQ, Molecular Genetics Centre - Malaga, Spain
MGZ München, Medizinisch Genetisches Zentrum München - München, Germany
Radboud University Nijmegen Medical Centre, Genome Diagnostics Nijmegen - Nijmegen, Netherlands
Ruhr University, Human Genetics - Bochum, Germany
Seoul National University Hospital, Molecular Diagnostics Laboratory - Seoul, South Korea
University Hospital Jena, Institute of Human Genetics - Jena, Germany	• Linkage analysis

^* Carrier column is relevant to autosomal recessive and X-linked inheritance; column will be blank when it is not relevant (e.g. autosomal dominant inheritance, microdeletions/duplications) and/or is not offered by the lab.