Disorders

Sick Sinus Syndrome 2, Autosomal Dominant

Synonym(s): Sinus Bradycardia Syndrome, Autosomal Dominant

Gene	Locus	Protein
HCN4	15q24.1	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

Laboratory	Test Method	Prenatal	Carrier *
Academic Medical Centre, University of Amsterdam, DNA Diagnostics Laboratory - Amsterdam, Netherlands	• Sequence analysis of the entire coding region
CeGaT GmbH - Tuebingen, Germany	• Sequence analysis of the entire coding region
PreventionGenetics, Clinical DNA Testing and DNA Banking - Marshfield, WI, USA	• Sequence analysis of the entire coding region • Deletion/duplication analysis
University Hospital Münster, Institute for Genetics of Heart Diseases (IfGH) - Münster, Germany	• Sequence analysis of the entire coding region

^* Carrier column is relevant to autosomal recessive and X-linked inheritance; column will be blank when it is not relevant (e.g. autosomal dominant inheritance, microdeletions/duplications) and/or is not offered by the lab.