Disorders

PMS2-Related Lynch Syndrome

Synonym(s): PMS2-Related Hereditary Non-Polyposis Colon Cancer, PMS2-Related HNPCC

Gene	Locus	Protein
PMS2	7p22.1	Epithelial cell adhesion molecule

Laboratory	Test Method	Prenatal	Carrier *
Academic Medical Centre, University of Amsterdam, DNA Diagnostics Laboratory - Amsterdam, Netherlands
Ambry Genetics Corp, Ambry Genetics - Aliso Viejo, CA, USA	• Immunohistochemistry
ARUP Laboratories, Molecular Genetics Laboratory - Salt Lake City, UT, USA	• Immunohistochemistry
Asper Biotech Ltd., Asper Biotech - Tartu, Estonia
Baylor College of Medicine, Medical Genetics Laboratories - Houston, TX, USA
Center for Human Genetics, Inc - Cambridge, MA, USA
Centogene AG, Rare Disease Company - Rostock, Germany
City of Hope National Medical Center, Clinical Molecular Diagnostic Laboratory - Duarte, CA, USA	• Immunohistochemistry
Diagenom GmbH, Medical Genetics Laboratory - Rostock, Germany
Dr. Eberhard and Partner, MVZ Dortmund - Dortmund, Germany
Emory University School of Medicine, Emory Molecular Genetics Laboratory - Atlanta, GA, USA	• Immunohistochemistry
GGA - Galil Genetic Analysis - Kazerin, Israel
Huntington Medical Research Institutes, Cancer Genetics Laboratory - Pasadena, CA, USA	• Sequence analysis of select exons • Immunohistochemistry
Klinikum Stuttgart, Institute of Clinical Genetics - Stuttgart, Germany
London Health Sciences Centre, Molecular Diagnostic Laboratory - London, Canada	• Immunohistochemistry
Mayo Clinic - Minnesota, Molecular Genetics Laboratory - Rochester, MN, USA	• Immunohistochemistry
MGZ München, Medizinisch Genetisches Zentrum München - München, Germany	• Immunohistochemistry
Myriad Genetic Laboratories, Inc., Myriad Genetic Laboratories - Salt Lake City, UT, USA
PreventionGenetics, Clinical DNA Testing and DNA Banking - Marshfield, WI, USA
Pronto Diagnostics Ltd., ProntoLab - MLPA Lab - Tel Aviv, Israel
Radboud University Nijmegen Medical Centre, Genome Diagnostics Nijmegen - Nijmegen, Netherlands
Samsung Medical Center, Department of Laboratory Medicine and Genetics - Seoul, South Korea
St James's University Hospital, Leeds Teaching Hospitals, Yorkshire Regional DNA Laboratory - Leeds, Great Britain	• Sequence analysis of select exons
University Children's Hospital, Labor Molekulargenetik, Abteilung Medizinische Genetik - Basel, Switzerland	• Linkage analysis
University Hospitals - University Hospitals Laboratory Service Foundation, Center for Human Genetics Laboratory - Cleveland, OH, USA
University of Washington Medical Center, Laboratory Medicine-Genetics Laboratory - Seattle, WA, USA

^* Carrier column is relevant to autosomal recessive and X-linked inheritance; column will be blank when it is not relevant (e.g. autosomal dominant inheritance, microdeletions/duplications) and/or is not offered by the lab.