Disorders

Leukodystrophy, Adult-Onset, Autosomal Dominant

Synonym(s): ADLD, Multiple Sclerosis-Like Disorder, Pelizaeus-Merzbacher Disease, Autosomal Dominant or Late-Onset Type

OMIM

Gene	Locus	Protein
LMNB1	5q23.2	Lamin-B1

Laboratory	Test Method	Prenatal	Carrier *
Alfred I. duPont Hospital for Children, Molecular Diagnostics Lab - Wilmington, DE, USA	• Deletion/duplication analysis
CeGaT GmbH - Tuebingen, Germany	• Sequence analysis of the entire coding region
Centogene AG, Rare Disease Company - Rostock, Germany	• Deletion/duplication analysis
PerkinElmer, Signature Genomic Laboratories - Spokane, WA, USA	• FISH-metaphase • FISH-interphase
Synlab MVZ Humane Genetik Mnchen, Labor fr Humangenetik - München, Germany	• Deletion/duplication analysis

^* Carrier column is relevant to autosomal recessive and X-linked inheritance; column will be blank when it is not relevant (e.g. autosomal dominant inheritance, microdeletions/duplications) and/or is not offered by the lab.