Disorders

CD46-Related Atypical Hemolytic-Uremic Syndrome

Gene	Locus	Protein
CD46	1q32	Membrane cofactor protein

Laboratory	Test Method	Prenatal	Carrier *
Center for Human Genetics, Bioscientia GmbH - Ingelheim, Germany	• Linkage analysis
Center for Nephrology and Metabolic Disorders, Laboratory for Molecular Diagnostics - Weisswasser, Germany
GENETAQ, Molecular Genetics Centre - Malaga, Spain
GGA - Galil Genetic Analysis - Kazerin, Israel
Hospital for Sick Children, Molecular Genetics Laboratory - Toronto, Canada
Newcastle Upon Tyne Hospitals NHS Foundation Trust, Northern Molecular Genetics Service - Newcastle Upon Tyne, Great Britain	• Protein analysis
PreventionGenetics, Clinical DNA Testing and DNA Banking - Marshfield, WI, USA
Pronto Diagnostics Ltd., ProntoLab - MLPA Lab - Tel Aviv, Israel
Radboud University Medical Centre, Laboratory of Genetic, Endocrine, and Metabolic Diseases - Nijmegen, Netherlands
Secugen SL - Madrid, Spain
University Medical Center Utrecht, Genome Diagnostics Laboratory - Utrecht, Netherlands
University of Iowa Hospital and Clinics, Molecular Otolaryngology and Renal Research Laboratories - Iowa City, IA, USA

^* Carrier column is relevant to autosomal recessive and X-linked inheritance; column will be blank when it is not relevant (e.g. autosomal dominant inheritance, microdeletions/duplications) and/or is not offered by the lab.