Disorders

Familial Platelet Disorder with Propensity to Acute Myelogenous Leukemia

Synonym(s): Aspirin-Like Platelet Disorder, Familial Platelet Disorder with Associated Myeloid Malignancy

Gene	Locus	Protein
RUNX1	21q22.3	Runt-related transcription factor 1

Laboratory	Test Method	Prenatal	Carrier *
Baylor College of Medicine, Medical Genetics Laboratories - Houston, TX, USA	• Sequence analysis of the entire coding region
BloodCenter of Wisconsin, Molecular Diagnostics Laboratory - Milwaukee, WI, USA	• Sequence analysis of the entire coding region
Institute of Medical and Veterinary Science, Molecular Pathology - Adelaide, Australia	• Sequence analysis of the entire coding region
PreventionGenetics, Clinical DNA Testing and DNA Banking - Marshfield, WI, USA	• Sequence analysis of the entire coding region • Deletion/duplication analysis
Radboud University Nijmegen Medical Centre, Genome Diagnostics Nijmegen - Nijmegen, Netherlands	• Sequence analysis of the entire coding region
University Medical Center Utrecht, Genome Diagnostics Laboratory - Utrecht, Netherlands	• Sequence analysis of the entire coding region

^* Carrier column is relevant to autosomal recessive and X-linked inheritance; column will be blank when it is not relevant (e.g. autosomal dominant inheritance, microdeletions/duplications) and/or is not offered by the lab.