Disorders

PROK2-Related Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency

Synonym(s): Hypogonadotropic Hypogonadism 4 with or without Anosmia , Hypogonadotropic Hypogonadism and Anosmia, Kallmann Syndrome 4

OMIM

Gene	Locus	Protein
PROK2	3p21.1	Prokineticin-2

Laboratory	Test Method	Prenatal	Carrier *
Athena Diagnostics Inc, Reference Lab - Worcester, MA, USA
bio.logis Center for Human Genetics - Frankfurt, Germany
Centogene AG, Rare Disease Company - Rostock, Germany
diagenos - Osnabrueck, Germany
Endokrinologikum Hamburg - Center for Hormonal and Metabolic Diseases, Prenatal, and Reproductive Medicine, Molecular Diagnostics - Hamburg, Germany
InVitae Corporation - San Francisco, CA, USA
Medgene, MedGene - Bratislava, Slovakia
Praxis fuer Humangenetik Wien - Vienna, Austria
Radboud University Nijmegen Medical Centre, Genome Diagnostics Nijmegen - Nijmegen, Netherlands

^* Carrier column is relevant to autosomal recessive and X-linked inheritance; column will be blank when it is not relevant (e.g. autosomal dominant inheritance, microdeletions/duplications) and/or is not offered by the lab.